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Daniel Choquet

Dr Daniel Choquet

  • Directeur de recherche au CNRS
  • Directeur de l'Institut Interdisciplinaire de Neuroscience, UMR 5297 CNRS - Université Bordeaux Segalen
  • Directeur du Bordeaux Imaging Center, UMS 3420 CNRS - INSERM - Université Bordeaux Segalen

Curriculum vitae

Date de naissance : 23 Avril 1962

Diplôme : Ingénieur de l'École Centrale des arts et manufacture de Paris

Contact

daniel.choquet @ u-bordeaux2.fr

Téléphone principal :
+33 5 57 57 40 90

Lien web : http://www.iins.u-bordeaux2.fr/research-teams/daniel-choquet-team

Adresse :
UNIVERSITE BORDEAUX SEGALEN
IINS : INSTITUT INTERDISCIP DE NEUROSCIENCE
UMR 5297 Institut F. Magendie
146 rue Léo Saignat
33077 BORDEAUX CEDEX

Structure

RECHERCHE

Thèmes de recherche

Daniel Choquet obtained an engineering degree from Ecole Centrale (Paris, France) in 1984. He then got attracted to neuroscience (Master’s degree Paris VI) and completed his Ph.D. in the lab of Henri Korn at the Pasteur Institute (Paris), studying ion channels in lymphocytes. He got appointed tenure Research officer at the CNRS in 1988 in the group of H. Korn. He then performed a post­doctoral/sabbatical at the Duke University (North Carolina, USA) in the laboratory of Michael Sheetz where he studied the regulation of integrin-cytoskeletal linkage by force, and demonstrated that cells can sense and respond to extracellular traction. He then setup his group in Bordeaux (France) at the Institute for Neuroscience where he got a directorship position at the CNRS. He launched an interdisciplinary program on the use of high resolution imaging to study the trafficking of neurotransmitter receptors in neural cells. He is now heading the project of the Institute for Interdisciplinary Neuroscience and the Bordeaux Imaging Center core facility. He develops several research topics, combining neuroscience, physics and chemistry in order to unravel the dynamics of multimolecular complexes and their role in synaptic transmission. He has recently uncovered a new role for the mobility of glutamate receptors in synaptic transmission.

He has been the recipient of several awards including the 1990 Bronze medal from the CNRS, the Research prize from the Fondation pour la Recherche Mdicale, 1997, the Grand Prix from the French Academy of Sciences, prix du CEA and the 2009  Silver medal from the CNRS. He is a Member of the Institut de France, the French Science Academy since November 2010.

The leitmotif of his research has always been to build bridges between disciplines in order to explore new scientific territories.

Publications

  • Bats, C., Groc, L., and Choquet, D. (2007). The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking.
    Neuron 53, 719-734.
  • Ehlers, M.D., Heine, M., Groc, L., Lee, M.C., and Choquet, D. (2007). Diffusional Trapping of GluR1 AMPA Receptors by Input-Specific Synaptic Activity.
    Neuron 54, 447-460.
  • Frischknecht+, R., Heine+, M., Perrais, D., Seidenbecher, C.I., Choquet*, D., Gundelfinger*, E.D., and +equal contribution, c.-s.a. (2009). The brain extracellular matrix limits lateral diffusion of AMPA receptors and modulates short-term synaptic plasticity.
    Nature Neuroscience 12 897-904.
  • Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F.A., Lounis, B., and Choquet, D. (2004). Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors.
    Nature Neuroscience 7, 695-696.
  • Heine, M., Groc, L., Frischknecht, R., Beique, J.C., Lounis, B., Rumbaugh, G., Huganir, R.L., Cognet, L., and Choquet, D. (2008). Surface mobility of postsynaptic AMPARs tunes synaptic transmission.
    Science 320, 201-205.
  • Opazo, P., Labrecque, S., Tigaret, C.M., Frouin, A., Wiseman, P.W., De Koninck, P., and Choquet, D. (2010). CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin.
    Neuron 67, 239-252.
  • Petrini, E.M., Lu, J., Cognet, L., Lounis, B., Ehlers, M.D., and Choquet, D. (2009). Endocytic trafficking and recycling maintain a pool of mobile surface AMPA receptors required for synaptic potentiation.
    Neuron 63, 92-105.
  • Sainlos, M., Tigaret, C., Poujol, C., Olivier, N.B., Bard, L., Breillat, C., Thiolon, K., Choquet, D., and Imperiali, B. (2011). Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.
    Nat Chem Biol 7, 81-91.
  • Triller, A., and Choquet, D. (2008). New concepts in synaptic biology derived from single-molecule imaging.
    Neuron 59, 359-374.
  • Triller, A., Choquet, D., and M-250 (2005). Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!
    Trends Neurosci 28, 133-139.